Lennart Husvogt
Lennart Husvogt, M. Sc.
Academic CV
- Since 05/2014:
Researcher at the Pattern Recognition Lab - 10/2016 – 10/2018
Research Affiliate at the Biomedical Optical Imaging and Biophotonics Group at MIT - 10/2016 – 10/2018
Research Assistant at the New England Eye Center at Tufts Medical Center - 10/2016 – 10/2018
Graduate Research Assistant at the Pattern Recognition Lab - 08/2014 – 08/2018
Visiting Student at the Biomedical Optical Imaging and Biophotonics Group at MIT
Projects
2017
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Joint Iterative Reconstruction and Motion Compensation for Optical Coherence Tomography Angiography
(Third Party Funds Single)
Term: August 1, 2017 - July 31, 2019
Funding source: DFG-Einzelförderung / Sachbeihilfe (EIN-SBH)Optical coherence tomography (OCT) is a non-invasive 3-D optical imagingmodality that is a standard of care in ophthalmology [1,2]. Since the introduction of Fourier-domain OCT [3], dramatic increases in imaging speedbecame possible, enabling 3-D volumetric data to be acquired. Typically, aregion of the retina is scanned line by line, where each scanned lineacquires a cross-sectional image or a B-scan. Since B-scans are acquiredin milliseconds, slices extracted along a scan line, or the fast scanaxis, are barely affected by motion. In contrast, slices extractedorthogonally to scan lines, i. e. in slow scan direction, areaffected by various types of eye motion occurring throughout the full,multi-second volume acquisition time. The most relevant types of eyemovements during acquisition are (micro-)saccades, which can introducediscontinuities or gaps between B-scans, and slow drifts, which causesmall, slowly changing distortion [4]. Additional eye motion is caused by pulsatile blood flow,respiration and head motion. Despite ongoing advances in instrumentscanning speed [5,6] typical volume acquisition times havenot decreased. Instead, the additional scanning speed is used for densevolumetric scanning or wider fields of view [7]. OCT angiography (OCTA) [8–11] multiplies therequired number of scans by at least two, and even more scans are neededto accommodate recent developments in blood flow speed estimation whichare based on multiple interscan times [12,13]. As a consequence,there is an ongoing need for improvement in motion compensation especiallyin pathology [14–16].
We develop novel methods for retrospective motion correction of OCT volume scans of the anterior and posterior eye, and widefield imaging. Our algorithms are clinically usable due to their suitability for patients with limited fixation capabilities and increased amount of motion, due to their fast processing speed, and their high accuracy, both in terms of alignment and motion correction. By merging multiple accurately aligned scans, image quality can be increased substantially, enabling the inspection of novel features.
Publications
2024
Journal Articles
Glaucoma detection using non-perfused areas in OCTA
In: Scientific Reports 14 (2024), Article No.: 10306
ISSN: 2045-2322
DOI: 10.1038/s41598-024-60839-4
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Ensembling U-Nets for microaneurysm segmentation in optical coherence tomography angiography in patients with diabetic retinopathy
In: Scientific Reports 14 (2024), Article No.: 21520
ISSN: 2045-2322
DOI: 10.1038/s41598-024-72375-2
URL: https://rdcu.be/dT0FK
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Impact of acquisition area on deep-learning-based glaucoma detection in different plexuses in OCTA
In: Scientific Reports 14 (2024), Article No.: 20414
ISSN: 2045-2322
DOI: 10.1038/s41598-024-71235-3
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2023
Conference Contributions
Advanced volume rebuilding overcomes quilting, stretching, and banding image artifacts in orthogonally-scanned OCT
Arvo Annual Meeting 2023 (New Orleans)
In: Investigative Ophthalmology & Visual Science 2023
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2789933
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Impact of acquisition area on deep-learning-based glaucoma detection in OCTA
ARVO annual meeting 2023 (New Orleans)
In: Investigative Ophthalmology & Visual Science 2023
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Abstract: A Spatiotemporal Model for Precise and Efficient Fully-automatic 3D Motion Correction in OCT
Bildverarbeitung für die Medizin Workshop, BVM 2023 (Braunschweig, DEU, July 2, 2023 - July 4, 2023)
In: Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus Maier-Hein, Christoph Palm, Thomas Tolxdorff (ed.): Informatik aktuell 2023
DOI: 10.1007/978-3-658-41657-7_57
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2022
Conference Contributions
A Spatiotemporal Model for Precise and Efficient Fully-Automatic 3D Motion Correction in OCT
25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022 (Singapore, SGP, September 18, 2022 - September 22, 2022)
In: Linwei Wang, Qi Dou, P. Thomas Fletcher, Stefanie Speidel, Shuo Li (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2022
DOI: 10.1007/978-3-031-16434-7_50
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Automatic identification of Microaneurysms in Diabetic Retinopathy patients utilizing an nn-UNet
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2022
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Ultrahigh resolution OCT, volume merging, and advanced signal reconstruction improve visualization of the RPE-Bruch's complex
In: Investigative Ophthalmology & Visual Science, Rockville: 2022
URL: https://iovs.arvojournals.org/article.aspx?articleid=2782224
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Unsupervised OCT Denoising using speckle split
ARVO annual meeting 2022 (Denver)
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2022
DOI: 10.1038/s41598-023-37324-5
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Form Follows Function: Smart Network Design Enables Zero-shot Network Reuse
German Workshop on Medical Image Computing, 2022 (Heidelberg, DEU, June 26, 2022 - June 28, 2022)
In: Klaus Maier-Hein, Thomas M. Deserno, Heinz Handels, Andreas Maier, Christoph Palm, Thomas Tolxdorff (ed.): Informatik aktuell 2022
DOI: 10.1007/978-3-658-36932-3_26
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2021
Journal Articles
Glaucoma classification in 3 x 3 mm en face macular scans using deep learning in a different plexus
In: Biomedical Optics Express 12 (2021), p. 7434-7444
ISSN: 2156-7085
DOI: 10.1364/BOE.439991
URL: https://opg.optica.org/boe/fulltext.cfm?uri=boe-12-12-7434&id=464725
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Efficient and high accuracy 3-D OCT angiography motion correction in pathology
In: Biomedical Optics Express 12 (2021), p. 125-146
ISSN: 2156-7085
DOI: 10.1364/BOE.411117
URL: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-125
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Maximum a posteriori signal recovery for optical coherence tomography angiography image generation and denoising
In: Biomedical Optics Express 12 (2021), p. 55-68
ISSN: 2156-7085
DOI: 10.1364/BOE.408903
URL: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-55&id=444277
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OCT-OCTA segmentation: Combining structural and blood flow information to segment bruch's membrane
In: Biomedical Optics Express 12 (2021), p. 84-99
ISSN: 2156-7085
DOI: 10.1364/BOE.398222
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Conference Contributions
Applying nnU-Net to the segmentation of microaneurysms in OCTA data in patients with non-proliferative diabetic retinopathy
ARVO Annual Meeting 2021
URL: https://iovs.arvojournals.org/article.aspx?articleid=2773716
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Deep Learning Glaucoma Classification in enface OCTA scans of the human macular region
ARVO Annual Meeting 2021
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2773575
URL: https://iovs.arvojournals.org/article.aspx?articleid=2773575
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Improved OCT motion correction in pathology using advanced eye motion modeling
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2021
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Abstract: Maximum A-posteriori Signal Recovery for OCT Angiography Image Generation
German Workshop on Medical Image Computing, 2021 (Regensburg, March 7, 2021 - March 9, 2021)
In: Christoph Palm, Heinz Handels, Klaus Maier-Hein, Thomas M. Deserno, Andreas Maier, Thomas Tolxdorff (ed.): Informatik aktuell 2021
DOI: 10.1007/978-3-658-33198-6_61
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2020
Conference Contributions
Compressed sensing for optical coherence tomography angiography volume generation
International workshop on Algorithmen - Systeme - Anwendungen, 2020 (Berlin, March 15, 2020 - March 17, 2020)
In: Thomas Tolxdorff, Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus H. Maier-Hein, Christoph Palm (ed.): Informatik aktuell 2020
DOI: 10.1007/978-3-658-29267-6_19
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Deep OCT angiography image generation for motion artifact suppression
International workshop on Algorithmen - Systeme - Anwendungen, 2020 (Berlin, March 15, 2020 - March 17, 2020)
In: Thomas Tolxdorff, Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus H. Maier-Hein, Christoph Palm (ed.): Informatik aktuell 2020
DOI: 10.1007/978-3-658-29267-6_55
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Modularization of deep networks allows cross-modality reuse: lesson learnt
International workshop on Algorithmen - Systeme - Anwendungen, 2020 (Berlin, March 15, 2020 - March 17, 2020)
In: Thomas Tolxdorff, Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus H. Maier-Hein, Christoph Palm (ed.): Informatik aktuell 2020
DOI: 10.1007/978-3-658-29267-6_61
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2019
Journal Articles
Spatial Distribution of Choriocapillaris Impairment in Eyes with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
In: Retina-The Journal of Retinal and Vitreous Diseases (2019)
ISSN: 0275-004X
DOI: 10.1097/IAE.0000000000002556
URL: https://journals.lww.com/retinajournal/Abstract/publishahead/SPATIAL_DISTRIBUTION_OF_CHORIOCAPILLARIS.96058.aspx
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Conference Contributions
Correction of artifacts from misregistered B-scans in orthogonally scanned and registered OCT angiography
ARVO Annual Meeting 2019 (Vancouver, B.C., Canada, April 28, 2019 - May 2, 2019)
In: Investigative Ophthalmology & Visual Science 2019
URL: https://iovs.arvojournals.org/article.aspx?articleid=2745781&resultClick=1
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Ultrahigh-Resolution SD-OCT of the Human Retina with Extended Imaging Range Using Reference Arm Length Modulation
ARVO Annual Meeting 2019 (Vancouver, B.C., Canada, April 28, 2019 - May 2, 2019)
In: Investigative Ophthalmology & Visual Science 2019
URL: https://iovs.arvojournals.org/article.aspx?articleid=2746181&resultClick=1
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Using Medical Image Reconstruction Methods for Denoising of OCTA Data
ARVO Annual Meeting 2019 (Vancouver, B.C., Canada, April 28, 2019 - May 2, 2019)
In: Investigative Ophthalmology & Visual Science 2019
URL: https://iovs.arvojournals.org/article.aspx?articleid=2746928&resultClick=1
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2018
Journal Articles
Temporal and Volumetric Denoising via Quantile Sparse Image Prior
In: Medical Image Analysis 48 (2018), p. 131-146
ISSN: 1361-8415
DOI: 10.1016/j.media.2018.06.002
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2018/Schirrmacher18-TAV.pdf
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Analyzing relative blood flow speeds in choroidal neovascularization using variable interscan time analysis OCT angiography
In: Ophthalmology Retina 2 (2018), p. 306-319
ISSN: 2468-7219
DOI: 10.1016/j.oret.2017.08.013
URL: https://www.sciencedirect.com/science/article/abs/pii/S2468653017303561?via=ihub
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Book Contributions
Optical Coherence Tomography
In: Andreas MaierStefan SteidlVincent ChristleinJoachim Hornegger (ed.): Medical Imaging Systems, Cham: Springer, 2018, p. 251-261 (Lecture Notes in Computer Science book series (LNCS), Vol.11111)
ISBN: 978-3-319-96520-8
DOI: 10.1007/978-3-319-96520-8_12
URL: https://link.springer.com/chapter/10.1007/978-3-319-96520-8_12
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Conference Contributions
Automatic detection of capillary dilation and looping in patients with diabetic retinopathy from optical coherence tomography angiography data
ARVO Annual Meeting 2018 (Honolulu, HI, USA, April 28, 2018 - May 3, 2018)
URL: https://iovs.arvojournals.org/article.aspx?articleid=2694335
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Efficient Labeling of Optical Coherence Tomography Angiography Data using Eye Tracking
Bildverarbeitung für die Medizin 2018 (Erlangen, March 11, 2018 - March 13, 2018)
In: Maier, Andreas Deserno, Thomas Martin Handels, Heinz Maier-Hein, Klaus Palm, Christoph Tolxdorff, Thomas (ed.): Bildverarbeitung für die Medizin 2018, Berlin, Heidelberg: 2018
DOI: 10.1007/978-3-662-56537-7_17
URL: https://link.springer.com/chapter/10.1007/978-3-662-56537-7_17
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First Approaches Towards Automatic Detection of Microaneurysms in OCTA Images
Bildverarbeitung für die Medizin 2018 (Erlangen, March 11, 2018 - March 13, 2018)
In: Maier, Andreas Deserno, Thomas Martin Handels, Heinz Maier-Hein, Klaus Palm, Christoph Tolxdorff, Thomas (ed.): Bildverarbeitung für die Medizin 2018, Berlin, Heidelberg: 2018
DOI: 10.1007/978-3-662-56537-7_11
URL: https://link.springer.com/chapter/10.1007/978-3-662-56537-7_11
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OCT-OCTA Segmentation
Bildverarbeitung für die Medizin 2018 (Erlangen, March 11, 2018 - March 13, 2018)
In: Maier, Andreas Deserno, Thomas Martin Handels, Heinz Maier-Hein, Klaus C., Palm Tolxdorff, Thomas (ed.): Bildverarbeitung für die Medizin 2018, Berlin: 2018
DOI: 10.1007/978-3-662-56537-7_76
URL: https://link.springer.com/chapter/10.1007/978-3-662-56537-7_76
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3-D OCT Motion Correction Efficiently Enhanced with OCT Angiography
ARVO annual meeting 2018
In: Investigative Ophthalmology & Visual Science 2018
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2694583
URL: https://iovs.arvojournals.org/article.aspx?articleid=2694583
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Abstract: QuaSI - Quantile Sparse Image A Prior for Spatio-Temporal Denoising of Retinal OCT Data
Bildverarbeitung für die Medizin 2018 (Erlangen)
In: Informatik aktuell 2018
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2018/Schirrmacher18-AQQ.pdf
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2017
Journal Articles
The Definition, Rationale, and Effects of Thresholding in OCT Angiography
In: Ophthalmology Retina 1/2017 (2017), p. 435-447
ISSN: 2468-7219
DOI: 10.1016/j.oret.2017.01.019
URL: https://www.sciencedirect.com/science/article/abs/pii/S2468653017300283
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Optical Coherence Tomography Angiography Characteristics of Iris Melanocytic Tumors
In: Ophthalmology 124 (2017), p. 197-204
ISSN: 0161-6420
DOI: 10.1016/j.ophtha.2016.10.003
URL: https://www.sciencedirect.com/science/article/pii/S0161642016313288#!
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Conference Contributions
Flow Void Analysis: Multiscale Quantitation and Visualization of Choriocapillaris Alterations in Age-Related Macular Degeneration Using OCT Angiography
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2637739&resultClick=1
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Alibhai17-FVA.pdf
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Hybrid OCT-OCTA Vessel Visualization for Projection-Free Display of the Intermediate and Deep Retinal Plexuses
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Ploner17-HOV.pdf
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OCT-OCTA Segmentation: a Novel Framework and an Application to Segment Bruch's Membrane in the Presence of Drusen
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Schottenhamml17-OSA.pdf
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Parallel Variable Interscan Time Analysis (VISTA) OCTA and en Face Doppler OCT of Optic Disc and Peripapillary Vasculature
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Lee17-PVI.pdf
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Smoothed and Resolved Thresholding (SmaRT-) Display: A New OCTA Display Technique to Resolve the Low Flow Ambiguity
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Yiu17-SAR.pdf
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Visualizing microvascular flow variation in OCTA using variable interscan time analysis (VISTA)
SPIE BiOS (San Francisco, CA, USA, January 28, 2017 - February 2, 2017)
In: Proc. SPIE 10053, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXI 2017
DOI: 10.1117/12.2254845
URL: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/10053/1/Visualizing-microvascular-flow-variation-in-OCTA-using-variable-interscan-time/10.1117/12.2254845.full?SSO=1
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QuaSI: Quantile Sparse Image Prior for Spatio-Temporal Denoising of Retinal OCT Data
Medical Image Computing and Computer-Assisted Intervention (Quebec City, QC, Canada, September 11, 2017 - September 13, 2017)
In: Medical Image Computing and Computer-Assisted Intervention - MICCAI 2017, Proceedings, Part II 2017
DOI: 10.1007/978-3-319-66185-8_10
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Schirrmacher17-QQS.pdf
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Variable Interscan Time Analysis (VISTA-) Optical Coherence Tomography Angiography (OCTA) of Blood Flow Speeds in Eyes with Diabetic Retinopathy
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science, ARVO: 2017
URL: https://iovs.arvojournals.org/article.aspx?articleid=2637998&resultClick=1
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2016
Journal Articles
An Automatic, Intercapillary Area-based Algorithm for Quantifying Diabetes-related Capillary Dropout Using Optical Coherence Tomography Angiography
In: Retina (Philadelphia, Pa.) 36 (2016), p. S93-S101
ISSN: 1539-2864
DOI: 10.1097/IAE.0000000000001288
URL: https://www.ncbi.nlm.nih.gov/pubmed/28005667
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Toward Quantitative Optical Coherence Tomography Angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis
In: Retina (Philadelphia, Pa.) 32 (2016), p. S118-S126
ISSN: 1539-2864
DOI: 10.1097/IAE.0000000000001328
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Virtual Hematoxylin and Eosin Transillumination Microscopy Using Epi-Fluorescence Imaging
In: PLoS ONE 11 (2016), p. 1-13
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0159337
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Giacomelli16-VHA.pdf
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Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography
In: Investigative Ophthalmology & Visual Science 57 (2016), p. OCT585-OCT590
ISSN: 0146-0404
DOI: 10.1167/iovs.15-18915
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Lane16-VTC.pdf
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Conference Contributions
An automatic algorithm measuring the retinal intercapillary area to assess diabetic retinopathy
ARVO Annual Meeting 2016 (Seattle, WA, USA, May 1, 2016 - May 5, 2016)
In: Investigative Ophthalmology & Visual Science 2016
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Schottenhamml16-AAA.pdf
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SlicerOCT: A 3-D visualization platform for orthoplane viewing of OCT(A) datasets
ARVO Annual Meeting 2016 (Seattle, WA, USA, May 1, 2016 - May 5, 2016)
In: Investigative Ophthalmology & Visual Science, ARVO: 2016
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Husvogt16-SA3.pdf
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Toward quantitative OCT angiography: visualizing flow impairment using variable interscan time analysis (VISTA)
ARVO Annual Meeting 2016 (Seattle, WA, USA, May 1, 2016 - May 5, 2016)
In: Investigative Ophthalmology & Visual Science 2016
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Ploner16-TQO.pdf
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Advanced Image Processing for Optical Coherence Tomography Angiography
10th Joint Workshop of the German Research Training Groups in Computer Science (Schloss Dagstuhl - Leibniz-Zentrum für Informatik)
In: Benedikt Etzold, René Richter, Maximilian Eibl, Wolfgang Lehner (ed.): Proceedings of the 10th Joint Workshop of the German Research Training Groups in Computer Science, Chemnitz: 2016
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Design of a portable wide field of view GPU-accelerated multiphoton imaging system for real-time imaging of breast surgical specimens
SPIE Photonics West (San-Francisco, CA, February 14, 2016 - February 16, 2016)
In: Multiphoton Microscopy in the Biomedical Sciences XVI 2016
DOI: 10.1117/12.2209241
URL: https://www.spiedigitallibrary.org/conference-proceedings-of-spie/9712/1/Design-of-a-portable-wide-field-of-view-GPU-accelerated/10.1117/12.2209241.full?SSO=1
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Choroidal Neovascularization Analyzed on Ultra-High Speed Swept Source Optical Coherence Tomography Angiography Compared to Spectral Domain Optical Coherence Tomography Angiography
ARVO Annual Meeting 2016 (Seattle, WA, USA, May 1, 2016 - May 5, 2016)
In: Investigative Ophthalmology & Visual Science, ARVO: 2016
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Louzada16-CNA.pdf
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