Ophthalmic Imaging
In the recent decade, ophthalmic imaging has proven to be a steadily growing field of research. A milestone in ophthalmology was the transfer of Optical Coherence Tomography (OCT) from research to clinical use. Compared to conventional fundus photography, OCT allows the three dimensional, depth resolved visualization of the human retina, while preserving the non-invasiveness. Recently, a radical change occured in the field of OCT research with the clinical introduction of OCT angiography (OCTA), which further adds dye-free imaging of the underlying vasculature.
Variable Interscan Time Analysis revealing slower blood flow in neovascularization in a PDR patient.
Research Focus
To facilitate an efficient analysis of this vastly increased amount of information, new processing algorithms are required to support the treating clinician. Our research focus is twofold: On the one hand, we develop advanced motion compensation, shadow artifact compensation and signal reconstruction algorithms to achieve artifact-free OCT(A) signals of best possible quality. On the other hand, we aid accurate image analysis by improving layer and vessel segmentations, categorizing vessels into arteries/veins or pathology. By combining both efforts, we want to improve the understanding of the most prevalent eye diseases, allowing for more accurate treatment and thus improved patient outcome.
Advanced shadow artifact removal reveals the unique structures of the retinal vascular networks.
Multidisciplinary Collaborations
To enable research with state-of-the-art technology while preserving a close link to the clinical needs, the work of our group is embedded in a multidisciplinary environment including optical engineers at the Massachusetts Institute of Technology, Cambridge, USA and clinicians at the New England Eye Center, Boston, USA and the Department of Ophthalmology at the University Clinic Erlangen.

Weilin Fu, M. Sc.
- Phone number: +49 9131 85 25246
- Email: weilin.fu@fau.de
- Website: https://lme.tf.fau.de/person/fu/

Lennart Husvogt, M. Sc.
- Phone number: +49 9131 85 25247
- Email: lennart.husvogt@fau.de
- Website: https://lme.tf.fau.de/person/husvogt/

Stefan Ploner, M. Sc.
- Phone number: +49 9131 85 28982
- Email: stefan.ploner@fau.de
- Website: https://lme.tf.fau.de/person/ploner/

Julia Schottenhamml, M. Sc.
- Phone number: +49 9131 85 27882
- Email: julia.schottenhamml@fau.de
- Website: https://lme.tf.fau.de/person/schottenhamml/
- Moult EM., Ploner S., Rebhun CB., Alibhai AY., Lee B., Moreira-Neto C., Novais EA., Schottenhamml J., Husvogt L., Maier A., Rosenfeld P., Duker JS., Waheed NK., Fujimoto JG.:
Variable Interscan Time Analysis (VISTA-) Optical Coherence Tomography Angiography (OCTA) of Blood Flow Speeds in Eyes with Diabetic Retinopathy
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science, ARVO: 2017
URL: https://iovs.arvojournals.org/article.aspx?articleid=2637998&resultClick=1
BibTeX: Download - Giacomelli M., Husvogt L., Vardeh H., Faulkner-Jones BE., Hornegger J., Connolly JL., Fujimoto JG.:
Virtual Hematoxylin and Eosin Transillumination Microscopy Using Epi-Fluorescence Imaging
In: PLoS ONE 11 (2016), p. 1-13
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0159337
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Giacomelli16-VHA.pdf
BibTeX: Download - Lane M., Moult EM., Novais EA., Louzada RN., Cole ED., Lee B., Husvogt L., Keane PA., Denniston AK., Witkin AJ., Baumal CR., Fujimoto JG., Duker JS., Waheed NK.:
Visualizing the Choriocapillaris Under Drusen: Comparing 1050-nm Swept-Source Versus 840-nm Spectral-Domain Optical Coherence Tomography Angiography
In: Investigative Ophthalmology & Visual Science 57 (2016), p. OCT585-OCT590
ISSN: 0146-0404
DOI: 10.1167/iovs.15-18915
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Lane16-VTC.pdf
BibTeX: Download - Schottenhamml J., Moult EM., Ploner S., Lee B., Novais EA., Cole ED., Dang S., Lu CD., Husvogt L., Waheed NK., Duker JS., Hornegger J., Fujimoto JG.:
An Automatic, Intercapillary Area-based Algorithm for Quantifying Diabetes-related Capillary Dropout Using Optical Coherence Tomography Angiography
In: Retina (Philadelphia, Pa.) 36 (2016), p. S93-S101
ISSN: 1539-2864
DOI: 10.1097/IAE.0000000000001288
URL: https://www.ncbi.nlm.nih.gov/pubmed/28005667
BibTeX: Download - Louzada RN., Novais EA., Adhi M., Cole ED., Moult EM., Husvogt L., Witkin AJ., Baumal CR., Fujimoto JG., Duker JS., Waheed NK.:
Choroidal Neovascularization Analyzed on Ultra-High Speed Swept Source Optical Coherence Tomography Angiography Compared to Spectral Domain Optical Coherence Tomography Angiography
ARVO Annual Meeting 2016 (Seattle, WA, USA, May 1, 2016 - May 5, 2016)
In: Investigative Ophthalmology & Visual Science, ARVO: 2016
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Louzada16-CNA.pdf
BibTeX: Download