Julia Schottenhamml
Julia Schottenhamml, M. Sc.
Academic CV
- Since 03/2018:
PhD Candidate at the Pattern Recognition Lab, Friedrich-Alexander University Erlangen-Nürnberg - 10/2015 – 09/2016:
Visiting Student at the Biomedical Optical Imaging and Biophotonics Group, Massachusetts Institute of Technology
- 04/2014 – 01/2018:
Master of Science in Computer Science, Friedrich-Alexander University Erlangen-Nürnberg - 10/2010 – 03/2014:
Bachelor of Science in Medical Engineering, Friedrich-Alexander University Erlangen-Nürnberg
Working Experience
Friedrich-Alexander-University Erlangen-Nürnberg
- 12/2016 – 03/2017:
Student research assistant, Digital Sports Group - 04/2015 – 10/2015:
Student teaching assistant, Exercises in Algorithms and Data Structures
- 06/2014 – 03/2015:
Student research assistant, Digital Sports Group - 04/2013 – 10/2013:
Student teaching assistant, Exercises in Algorithms and Data Structures - 10/2012 – 04/2013:
Student teaching assistant, Exercises in Signals and Systems 1
Massachusetts Institute of Technology
- 10/2015 – 09/2016:
Visiting Student at the Biomedical Optical Imaging and Biophotonics Group, Massachusetts Institute of Technology
Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRMII)
- 01/2014 – 02/2014:
Internship, Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRMII), Munich
Awards
- 2017: MIT Outstanding Poster Award at ARVO 2017
- 2017: Grant Wood Balkema Memorial Travel Grant
Projects
- Unsupervised OCTA preserving OCT denoising
Denoising in Optical Coherence Tomography (OCT) and OCT angiography (OCTA) is a very important topic in order to compensate the low signal to noise ratio inherent to that technology. However, the speckle in OCT images consists not only of speckle noise but also of speckle information caused by the movement of blood cells in the vessels. This information is actually used to compute the OCTA images from OCT scans. All existing denoising methods at the moment do not distinguish between speckle noise and speckle information and therefore eradicate the information as well as the speckle. Another drawback is that because of the nature of OCT devices, no ground truth can be generated. At the moment this is solved by acquiring multiple scans an performing an averaging. This has the downside that a very good registration is needed and that scan times are longer, which may cause problems in elderly people or people with certain pathologies that have a hard time focusing. We therefore investigate unsupervised methods to distinguish between speckle information and speckle noise and only remove the latter.
This project is carried out in collaboration with Prof. Fujimoto’s Biomedical Optical Imaging and Biophotonics Group at MIT in Cambridge, USA and the opthalmic clinic of the university hospital Erlangen. - OCT-OCTA Segmentation of the Bruch’s Membrane in the Presence of Pathology:
Because of the ever increasing size of OCT(A) data sets, manual segmentation of ocular layers is typically impractically laborious, necessitating the usage of automatic algorithms. While automatic segmentation of ocular layers in the normal eye can be challenging, automatic segmentation in the presence of pathology, which often causes significant ocular distortions, is more challenging still.Perhaps nowhere is the demand for accurate segmentation more stringent than in OCTA analysis of the choriocapillaris. Analysis of the choriocapillaris is of great interest in studying a number of diseases, including age-related macular degeneration (AMD) and diabetic retinopathy (DR), where the choriocapillaris is thought to play an important role. En face OCTA analysis of the choriocapillaris typically requires segmentation of Bruch’s membrane (BM), an acellular matrix situated between the retinal pigment epithelium (RPE) and choriocapillaris. However, to our knowledge, all previous publications on segmenting the BM have exclusively used OCT data. We think that OCTA data can be used synergistically alongside OCT data to segment Bruch’s membrane, as well as other ocular structures. As such, the scope of this project is to explore different ways of incorporating and exploiting the additional information provided by the OCTA data in order to get more accurate and robust segmentation results for the BM in the presence of pathology.
This project is carried out in collaboration with Prof. Fujimoto’s Biomedical Optical Imaging and Biophotonics Group at MIT in Cambridge, USA.
2019
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PPP Brasilien 2019
(Third Party Funds Single)
Term: January 1, 2019 - December 31, 2020
Funding source: Deutscher Akademischer Austauschdienst (DAAD)
2018
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Automatic Intraoperative Tracking for Workflow and Dose Monitoring in X-Ray-based Minimally Invasive Surgeries
(Third Party Funds Single)
Term: June 1, 2018 - May 31, 2021
Funding source: Bundesministerium für Bildung und Forschung (BMBF)The goal of this project is the investigation of multimodal methods for the evaluation of interventional workflows in the operation room. This topic will be researched in an international project context with partners in Germany and in Brazil (UNISINOS in Porto Alegre). Methods will be developed to analyze the processes in an OR based on signals from body-worn sensors, cameras and other modalities like X-ray images recorded during the surgeries. For data analysis, techniques from the field of computer vision, machine learning and pattern recognition will be applied. The system will be integrated in a way that body-worn sensors developed by Portabiles as well as angiography systems produced by Siemens Healthcare can be included alongside.
Publications
2024
Journal Articles
Glaucoma detection using non-perfused areas in OCTA
In: Scientific Reports 14 (2024), Article No.: 10306
ISSN: 2045-2322
DOI: 10.1038/s41598-024-60839-4
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Ensembling U-Nets for microaneurysm segmentation in optical coherence tomography angiography in patients with diabetic retinopathy
In: Scientific Reports 14 (2024), Article No.: 21520
ISSN: 2045-2322
DOI: 10.1038/s41598-024-72375-2
URL: https://rdcu.be/dT0FK
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Impact of acquisition area on deep-learning-based glaucoma detection in different plexuses in OCTA
In: Scientific Reports 14 (2024), Article No.: 20414
ISSN: 2045-2322
DOI: 10.1038/s41598-024-71235-3
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2023
Journal Articles
APSified OCT-angiography analysis: Macula vessel density in healthy eyes during office hours
In: PLoS ONE 18 (2023), Article No.: e0282827
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0282827
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Conference Contributions
A Spatiotemporal Illumination Model for 3d Image Fusion in Optical Coherence Tomography
IEEE International Symposium on Biomedical Imaging (Cartagena, April 18, 2023 - April 21, 2023)
In: 2023 IEEE 20th International Symposium on Biomedical Imaging 2023
DOI: 10.1109/ISBI53787.2023.10230526
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Advanced volume rebuilding overcomes quilting, stretching, and banding image artifacts in orthogonally-scanned OCT
Arvo Annual Meeting 2023 (New Orleans)
In: Investigative Ophthalmology & Visual Science 2023
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2789933
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Impact of acquisition area on deep-learning-based glaucoma detection in OCTA
ARVO annual meeting 2023 (New Orleans)
In: Investigative Ophthalmology & Visual Science 2023
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Abstract: A Spatiotemporal Model for Precise and Efficient Fully-automatic 3D Motion Correction in OCT
Bildverarbeitung für die Medizin Workshop, BVM 2023 (Braunschweig, DEU, July 2, 2023 - July 4, 2023)
In: Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus Maier-Hein, Christoph Palm, Thomas Tolxdorff (ed.): Informatik aktuell 2023
DOI: 10.1007/978-3-658-41657-7_57
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2022
Journal Articles
Applications of Artificial Intelligence in Optical Coherence Tomography Angiography Imaging
In: Klinische Monatsblätter für Augenheilkunde 239 (2022), p. 1412-1426
ISSN: 0023-2165
DOI: 10.1055/a-1961-7137
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Post-COVID-19 Syndrome: Retinal Microcirculation as a Potential Marker for Chronic Fatigue
In: International Journal of Molecular Sciences 23 (2022), Article No.: 13683
ISSN: 1422-0067
DOI: 10.3390/ijms232213683
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Long COVID: Association of Functional Autoantibodies against G-Protein-Coupled Receptors with an Impaired Retinal Microcirculation
In: International Journal of Molecular Sciences 23 (2022), Article No.: 7209
ISSN: 1422-0067
DOI: 10.3390/ijms23137209
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Reference database of total retinal vessel surface area derived from volume-rendered optical coherence tomography angiography
In: Scientific Reports 12 (2022), p. 3695-
ISSN: 2045-2322
DOI: 10.1038/s41598-022-07439-2
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Conference Contributions
A Spatiotemporal Model for Precise and Efficient Fully-Automatic 3D Motion Correction in OCT
25th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2022 (Singapore, SGP, September 18, 2022 - September 22, 2022)
In: Linwei Wang, Qi Dou, P. Thomas Fletcher, Stefanie Speidel, Shuo Li (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2022
DOI: 10.1007/978-3-031-16434-7_50
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Possible Impact of functional active GPCR-autoantibodies on retinal microcirculation in Long-COVID
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2022
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Ultrahigh resolution OCT, volume merging, and advanced signal reconstruction improve visualization of the RPE-Bruch's complex
In: Investigative Ophthalmology & Visual Science, Rockville: 2022
URL: https://iovs.arvojournals.org/article.aspx?articleid=2782224
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Unsupervised OCT Denoising using speckle split
ARVO annual meeting 2022 (Denver)
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2022
DOI: 10.1038/s41598-023-37324-5
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2021
Journal Articles
Glaucoma classification in 3 x 3 mm en face macular scans using deep learning in a different plexus
In: Biomedical Optics Express 12 (2021), p. 7434-7444
ISSN: 2156-7085
DOI: 10.1364/BOE.439991
URL: https://opg.optica.org/boe/fulltext.cfm?uri=boe-12-12-7434&id=464725
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Case Report: Neutralization of Autoantibodies Targeting G-Protein-Coupled Receptors Improves Capillary Impairment and Fatigue Symptoms After COVID-19 Infection
In: Frontiers in Medicine 8 (2021), Article No.: 754667
ISSN: 2296-858X
DOI: 10.3389/fmed.2021.754667
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NEGATIVE VESSEL REMODELING IN STARGARDT DISEASE QUANTIFIED WITH VOLUME-RENDERED OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY
In: Retina (Philadelphia, Pa.) 41 (2021), p. 1948-1957
ISSN: 1539-2864
DOI: 10.1097/IAE.0000000000003110
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Efficient and high accuracy 3-D OCT angiography motion correction in pathology
In: Biomedical Optics Express 12 (2021), p. 125-146
ISSN: 2156-7085
DOI: 10.1364/BOE.411117
URL: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-125
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Maximum a posteriori signal recovery for optical coherence tomography angiography image generation and denoising
In: Biomedical Optics Express 12 (2021), p. 55-68
ISSN: 2156-7085
DOI: 10.1364/BOE.408903
URL: https://www.osapublishing.org/boe/fulltext.cfm?uri=boe-12-1-55&id=444277
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OCT-OCTA segmentation: Combining structural and blood flow information to segment bruch's membrane
In: Biomedical Optics Express 12 (2021), p. 84-99
ISSN: 2156-7085
DOI: 10.1364/BOE.398222
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Conference Contributions
Applying nnU-Net to the segmentation of microaneurysms in OCTA data in patients with non-proliferative diabetic retinopathy
ARVO Annual Meeting 2021
URL: https://iovs.arvojournals.org/article.aspx?articleid=2773716
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'APSifyed' Bruch's membrane opening (BMO) based peripapillary OCT-A analysis
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2021
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Deep Learning Glaucoma Classification in enface OCTA scans of the human macular region
ARVO Annual Meeting 2021
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2773575
URL: https://iovs.arvojournals.org/article.aspx?articleid=2773575
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Improved OCT motion correction in pathology using advanced eye motion modeling
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2021
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Analysis of Interventional Workflow Phases based on Image Classification
65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS) (Berlin (online conference), September 6, 2020 - September 9, 2020)
In: 65th Annual Meeting of the German Association for Medical Informatics, Biometry and Epidemiology (GMDS) 2021
DOI: 10.3205/20gmds187
URL: https://www.egms.de/static/en/meetings/gmds2020/20gmds187.shtml
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Abstract: Maximum A-posteriori Signal Recovery for OCT Angiography Image Generation
German Workshop on Medical Image Computing, 2021 (Regensburg, March 7, 2021 - March 9, 2021)
In: Christoph Palm, Heinz Handels, Klaus Maier-Hein, Thomas M. Deserno, Andreas Maier, Thomas Tolxdorff (ed.): Informatik aktuell 2021
DOI: 10.1007/978-3-658-33198-6_61
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RGB-D-based Human Detection and Segmentation for Mobile Robot Navigation in Industrial Environments
16th International Joint Conference on Computer Vision, Imaging and Computer Graphics Theory and Applications (VISIGRAPP 2021) (, February 8, 2021 - February 10, 2021)
DOI: 10.5220/0010187702190226
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2020
Journal Articles
Novel biomarker of sphericity and cylindricity indices in volume-rendering optical coherence tomography angiography in normal and diabetic eyes: a preliminary study
In: Graefes Archive For Clinical and Experimental Ophthalmology (2020)
ISSN: 0721-832X
DOI: 10.1007/s00417-019-04582-x
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Conference Contributions
Fully automatic separation of three capillary plexuses in the macular region
Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) (ONLINE, May 1, 2020 - May 7, 2020)
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2020
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3-D tracing of capillaries through three retinal vascular plexuses toward their closest superficial artery and vein in OCT angiography volumes
ARVO annual meeting 2020
In: Investigative Ophthalmology & Visual Science 2020
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2770859
URL: https://iovs.arvojournals.org/article.aspx?articleid=2770859
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Compressed sensing for optical coherence tomography angiography volume generation
International workshop on Algorithmen - Systeme - Anwendungen, 2020 (Berlin, March 15, 2020 - March 17, 2020)
In: Thomas Tolxdorff, Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus H. Maier-Hein, Christoph Palm (ed.): Informatik aktuell 2020
DOI: 10.1007/978-3-658-29267-6_19
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2019
Journal Articles
Spatial Distribution of Choriocapillaris Impairment in Eyes with Choroidal Neovascularization Secondary to Age-Related Macular Degeneration
In: Retina-The Journal of Retinal and Vitreous Diseases (2019)
ISSN: 0275-004X
DOI: 10.1097/IAE.0000000000002556
URL: https://journals.lww.com/retinajournal/Abstract/publishahead/SPATIAL_DISTRIBUTION_OF_CHORIOCAPILLARIS.96058.aspx
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Conference Contributions
Correction of artifacts from misregistered B-scans in orthogonally scanned and registered OCT angiography
ARVO Annual Meeting 2019 (Vancouver, B.C., Canada, April 28, 2019 - May 2, 2019)
In: Investigative Ophthalmology & Visual Science 2019
URL: https://iovs.arvojournals.org/article.aspx?articleid=2745781&resultClick=1
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Deep learning based hybrid OCT-OCTA segmentation of Bruch's membrane in pathology
Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) (Vancouver, April 28, 2019 - May 2, 2019)
In: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ROCKVILLE: 2019
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Using Medical Image Reconstruction Methods for Denoising of OCTA Data
ARVO Annual Meeting 2019 (Vancouver, B.C., Canada, April 28, 2019 - May 2, 2019)
In: Investigative Ophthalmology & Visual Science 2019
URL: https://iovs.arvojournals.org/article.aspx?articleid=2746928&resultClick=1
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Analysis by adversarial synthesis - A novel approach for speech vocoding
20th Annual Conference of the International Speech Communication Association: Crossroads of Speech and Language, INTERSPEECH 2019 (Graz, AUT, September 15, 2019 - September 19, 2019)
In: Gernot Kubin, Thomas Hain, Bjorn Schuller, Dina El Zarka, Petra Hodl (ed.): Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH 2019
DOI: 10.21437/Interspeech.2019-1195
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Unobtrusive Estimation of In-Stroke Boat Rotation in Rowing Using Wearable Sensors
12th International Symposium on Computer Science in Sport (IACSS) (Moscow, Russia, July 8, 2019 - July 10, 2019)
In: Springer (ed.): Proceedings of the 12th International Symposium on Computer Science in Sport (IACSS 2019) 2019
DOI: 10.1007/978-3-030-35048-2_14
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2018
Journal Articles
Analyzing relative blood flow speeds in choroidal neovascularization using variable interscan time analysis OCT angiography
In: Ophthalmology Retina 2 (2018), p. 306-319
ISSN: 2468-7219
DOI: 10.1016/j.oret.2017.08.013
URL: https://www.sciencedirect.com/science/article/abs/pii/S2468653017303561?via=ihub
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Conference Contributions
A Joint Probabilistic Model for Speckle Variance, Amplitude Decorrelation and Interframe Variance (IFV) Optical Coherence Tomography Angiography
Bildverarbeitung für die Medizin 2018 - Algorithmen - Systeme - Anwendungen (Erlangen, March 11, 2018 - March 13, 2018)
In: Proceedings des Workshops Bildverarbeitung für die Medizin 2018 - Algorithmen - Systeme - Anwendungen 2018
DOI: 10.1007/978-3-662-56537-7_37
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OCT-OCTA Segmentation
Bildverarbeitung für die Medizin 2018 (Erlangen, March 11, 2018 - March 13, 2018)
In: Maier, Andreas Deserno, Thomas Martin Handels, Heinz Maier-Hein, Klaus C., Palm Tolxdorff, Thomas (ed.): Bildverarbeitung für die Medizin 2018, Berlin: 2018
DOI: 10.1007/978-3-662-56537-7_76
URL: https://link.springer.com/chapter/10.1007/978-3-662-56537-7_76
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3-D OCT Motion Correction Efficiently Enhanced with OCT Angiography
ARVO annual meeting 2018
In: Investigative Ophthalmology & Visual Science 2018
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2694583
URL: https://iovs.arvojournals.org/article.aspx?articleid=2694583
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2017
Journal Articles
The Definition, Rationale, and Effects of Thresholding in OCT Angiography
In: Ophthalmology Retina 1/2017 (2017), p. 435-447
ISSN: 2468-7219
DOI: 10.1016/j.oret.2017.01.019
URL: https://www.sciencedirect.com/science/article/abs/pii/S2468653017300283
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Photoreceptor Layer Thickness Changes During Dark Adaptation Observed With Ultrahigh-Resolution Optical Coherence Tomography
In: Investigative Ophthalmology & Visual Science 58 (2017), p. 4632-4643
ISSN: 0146-0404
DOI: 10.1167/iovs.17-22171
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Conference Contributions
Flow Void Analysis: Multiscale Quantitation and Visualization of Choriocapillaris Alterations in Age-Related Macular Degeneration Using OCT Angiography
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2637739&resultClick=1
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Alibhai17-FVA.pdf
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Hybrid OCT-OCTA Vessel Visualization for Projection-Free Display of the Intermediate and Deep Retinal Plexuses
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Ploner17-HOV.pdf
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OCT-OCTA Segmentation: a Novel Framework and an Application to Segment Bruch's Membrane in the Presence of Drusen
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Schottenhamml17-OSA.pdf
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Analysis of Polypoidal Choroidal Vasculopathy Using Swept Source Optical Coherence Tomography Angiography with Variable Interscan Time Analysis
ARVO Annual Meeting 2017 (Baltimore, MD, USA)
In: Investigative Ophthalmology & Visual Science, ARVO: 2017
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2017/Moreira-Neto17-AOP.pdf
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Variable Interscan Time Analysis (VISTA-) Optical Coherence Tomography Angiography (OCTA) of Blood Flow Speeds in Eyes with Diabetic Retinopathy
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science, ARVO: 2017
URL: https://iovs.arvojournals.org/article.aspx?articleid=2637998&resultClick=1
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Visualizing Relative Blood Flow Speeds in Choroidal Neovascularization Using Variable Interscan Time Analysis (VISTA-) Optical Coherence Tomography Angiography (OCTA)
ARVO Annual Meeting 2017 (Baltimore, MD, USA, May 7, 2017 - May 11, 2017)
In: Investigative Ophthalmology & Visual Science 2017
Open Access: https://iovs.arvojournals.org/article.aspx?articleid=2637740
URL: https://iovs.arvojournals.org/article.aspx?articleid=2637740
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2016
Journal Articles
An Automatic, Intercapillary Area-based Algorithm for Quantifying Diabetes-related Capillary Dropout Using Optical Coherence Tomography Angiography
In: Retina (Philadelphia, Pa.) 36 (2016), p. S93-S101
ISSN: 1539-2864
DOI: 10.1097/IAE.0000000000001288
URL: https://www.ncbi.nlm.nih.gov/pubmed/28005667
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Toward Quantitative Optical Coherence Tomography Angiography: Visualizing Blood Flow Speeds in Ocular Pathology Using Variable Interscan Time Analysis
In: Retina (Philadelphia, Pa.) 32 (2016), p. S118-S126
ISSN: 1539-2864
DOI: 10.1097/IAE.0000000000001328
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Conference Contributions
An automatic algorithm measuring the retinal intercapillary area to assess diabetic retinopathy
ARVO Annual Meeting 2016 (Seattle, WA, USA, May 1, 2016 - May 5, 2016)
In: Investigative Ophthalmology & Visual Science 2016
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Schottenhamml16-AAA.pdf
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Toward quantitative OCT angiography: visualizing flow impairment using variable interscan time analysis (VISTA)
ARVO Annual Meeting 2016 (Seattle, WA, USA, May 1, 2016 - May 5, 2016)
In: Investigative Ophthalmology & Visual Science 2016
URL: https://www5.informatik.uni-erlangen.de/Forschung/Publikationen/2016/Ploner16-TQO.pdf
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2014
Journal Articles
Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization
In: Biomedical Optics Express 5 (2014), p. 2591-2613
ISSN: 2156-7085
DOI: 10.1364/BOE.5.002591
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