Learning Algorithms for Medical Big Data Analysis (LAMBDA)

This group is concerned with applying the most advanced learning approaches on multi-modal, medical imaging for the improvement of clinical decision making. Current topics of interest include identification of a malignant tumor sub-types in breast cancer, establishing correlations between image-based features, gene expression and disease progression in patients, and developing innovative therapeutic approaches such as immune cell guidance and response activation.


In clinical settings, different data is stored in different systems. These data are very heterogeneous, but still highly interconnected. Graph databases are a good fit for this kind of data: they contain heterogeneous "data nodes" which can be connected to each other. The basic question is now if and how clinical data can be used in a graph database, most importantly how clinical staff can profit from this approach. Possible scenarios are a graphical user interface for clinical staff for easier…

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Breast cancer is the leading cause of cancer related deaths in women, the second most common cancer worldwide. The development and progression of breast cancer is a dynamic biological and evolutionary process. It involves a composite organ system, with transcriptome shaped by gene aberrations, epigenetic changes, the cellular biological context, and environmental influences. Breast cancer growth and response to treatment has a number of characteristics that are specific to the individual patient,…

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Cardiovascular diseases (CVDs) and other cardiac pathologies are the leading cause of death in Europe and the USA. Timely diagnosis and post-treatment follow-ups are imperative for improving survival rates and delivering high-quality patient care. These steps rely heavily on numerous cardiac imaging modalities, which include CT (computerized tomography), coronary angiography and cardiac MRI. Cardiac MRI is a non-invasive imaging modality used to detect and monitor cardiovascular diseases. Consequently,…

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