Frauke Wilm

2026

Journal Articles

• Öttl M., Mei S., Wilm F., Qiu J., Steenpaß J., Rübner M., Hartmann A., Hübner H., Fasching P., Maier A., Erber R., Breininger K.:
  Analyzing and adapting diffusion segmentation behavior for medical images
  In: Biomedical Signal Processing and Control 112 (2026), Article No.: 108619
  ISSN: 1746-8094
  DOI: 10.1016/j.bspc.2025.108619
  BibTeX: Download

2025

Journal Articles

• Öttl M., Steenpaß J., Wilm F., Qiu J., Rübner M., Lang-Schwarz C., Taverna C., Tava F., Hartmann A., Hübner H., Beckmann M., Fasching P., Maier A., Erber R., Breininger K.:
  Fully automatic HER2 tissue segmentation for interpretable HER2 scoring
  In: Journal of Pathology Informatics 17 (2025), Article No.: 100435
  ISSN: 2229-5089
  DOI: 10.1016/j.jpi.2025.100435
  BibTeX: Download
• Ammeling J., Ganz J., Wilm F., Breininger K., Aubreville M.:
  Investigation of Class Separability within Object Detection Models in Histopathology
  In: IEEE Transactions on Medical Imaging (2025)
  ISSN: 0278-0062
  DOI: 10.1109/TMI.2025.3560134
  BibTeX: Download

Conference Contributions

• Qiu J., Aubreville M., Wilm F., Öttl M., Utz J., Schlereth M., Breininger K.:
  Abstract: Leveraging Image Captions for Selective Whole Slide Image Annotation
  German Conference on Medical Image Computing (Regensburg, March 9, 2025 - March 11, 2025)
  In: Bildverarbeitung für die Medizin 2025, Wiesbaden: 2025
  DOI: 10.1007/978-3-658-47422-5_59
  BibTeX: Download
• Rivera Monroy LC., Rist L., Wilm F., Ostalecki C., Baur A., Vera González J., Breininger K., Maier A.:
  Abstract: Multi-level Cancer Profiling through Joint Cell-graph Representations
  German Conference on Medical Image Computing (Regensburg, March 9, 2025 - March 11, 2025)
  In: Bildverarbeitung für die Medizin 2025 2025
  DOI: 10.1007/978-3-658-47422-5_34
  BibTeX: Download
• Öttl M., Wilm F., Steenpaß J., Qiu J., Rübner M., Hartmann A., Beckmann M., Fasching P., Maier A., Erber R., Kainz B., Breininger K.:
  Style-Extracting Diffusion Models for Semi-supervised Histopathology Segmentation
  18th European Conference on Computer Vision, ECCV 2024 (Milan, September 29, 2024 - October 4, 2024)
  In: Aleš Leonardis, Elisa Ricci, Stefan Roth, Olga Russakovsky, Torsten Sattler, Gül Varol (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2025
  DOI: 10.1007/978-3-031-73226-3_14
  BibTeX: Download

Thesis

• Wilm F.:
  Cross-Domain Generalization of Deep Learning-Based Image Analysis Algorithms in Histopathology (Dissertation, 2025)
  DOI: 10.25593/open-fau-1699
  URL: https://open.fau.de/handle/openfau/35170
  BibTeX: Download

2024

Journal Articles

• Aubreville M., Wilm F., Stathonikos N., Breininger K., Donovan TA., Jabari S., Veta M., Ganz J., Ammeling J., van Diest PJ., Klopfleisch R., Bertram CA.:
  Author Correction: A comprehensive multi-domain dataset for mitotic figure detection (Scientific Data, (2023), 10, 1, (484), 10.1038/s41597-023-02327-4)
  In: Scientific Data 11 (2024), Article No.: 717
  ISSN: 2052-4463
  DOI: 10.1038/s41597-024-03548-x
  BibTeX: Download
• Stathonikos N., Aubreville M., de Vries S., Wilm F., Bertram CA., Veta M., van Diest PJ.:
  Breast cancer survival prediction using an automated mitosis detection pipeline
  In: Journal of Pathology: Clinical Research 10 (2024), Article No.: e70008
  ISSN: 2056-4538
  DOI: 10.1002/2056-4538.70008
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• Aubreville M., Stathonikos N., Donovan TA., Klopfleisch R., Ammeling J., Ganz J., Wilm F., Veta M., Jabari S., Eckstein M., Annuscheit J., Krumnow C., Bozaba E., Çayır S., Gu H., Chen X‘., Jahanifar M., Shephard A., Kondo S., Kasai S., Kotte S., Saipradeep VG., Lafarge MW., Koelzer VH., Wang Z., Zhang Y., Yang S., Wang X., Breininger K., Bertram CA.:
  Domain generalization across tumor types, laboratories, and species — Insights from the 2022 edition of the Mitosis Domain Generalization Challenge
  In: Medical Image Analysis 94 (2024), Article No.: 103155
  ISSN: 1361-8415
  DOI: 10.1016/j.media.2024.103155
  BibTeX: Download
• Rivera Monroy LC., Rist L., Wilm F., Ostalecki C., Baur A., Vera González J., Breininger K., Maier A.:
  Multi-level cancer profiling through joint cell-graph representations
  In: Smart Health 32 (2024), p. 100470
  ISSN: 2352-6483
  DOI: 10.1016/j.smhl.2024.100470
  BibTeX: Download

Conference Contributions

• Wilm F., Reimann MK., Taubmann O., Mühlberg A., Breininger K.:
  Appearance-based Debiasing of Deep Learning Models in Medical Imaging
  German Conference on Medical Image Computing, BVM 2024 (Erlangen, March 10, 2024 - March 12, 2024)
  In: Andreas Maier, Thomas M. Deserno, Heinz Handels, Klaus Maier-Hein, Christoph Palm, Thomas Tolxdorff (ed.): Bildverarbeitung für die Medizin 2024. BVM 2024, Wiesbaden: 2024
  DOI: 10.1007/978-3-658-44037-4_9
  BibTeX: Download
• Qiu J., Aubreville M., Wilm F., Öttl M., Utz J., Schlereth M., Breininger K.:
  Leveraging Image Captions for Selective Whole Slide Image Annotation
  27th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2024 (Marrakesh, October 6, 2024 - October 10, 2024)
  In: Marius George Linguraru, Qi Dou, Aasa Feragen, Stamatia Giannarou, Ben Glocker, Karim Lekadir, Julia A. Schnabel (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2024
  DOI: 10.1007/978-3-031-72390-2_20
  BibTeX: Download

2023

Journal Articles

• Aubreville M., Wilm F., Stathonikos N., Breininger K., Donovan TA., Jabari S., Veta M., Ganz J., Ammeling J., van Diest PJ., Klopfleisch R., Bertram CA.:
  A comprehensive multi-domain dataset for mitotic figure detection
  In: Scientific Data 10 (2023), Article No.: 484
  ISSN: 2052-4463
  DOI: 10.1038/s41597-023-02327-4
  BibTeX: Download
• Wilm F., Ihling C., Méhes G., Terracciano L., Puget C., Klopfleisch R., Schüffler P., Aubreville M., Maier A., Mrowiec T., Breininger K.:
  Pan-tumor T-lymphocyte detection using deep neural networks: Recommendations for transfer learning in immunohistochemistry
  In: Journal of Pathology Informatics 14 (2023), Article No.: 100301
  ISSN: 2229-5089
  DOI: 10.1016/j.jpi.2023.100301
  BibTeX: Download
• Aubreville M., Stathonikos N., Bertram CA., Klopfleisch R., ter Hoeve N., Ciompi F., Wilm F., Marzahl C., Donovan TA., Maier A., Breen J., Ravikumar N., Chung Y., Park J., Nateghi R., Pourakpour F., Fick RH., Ben Hadj S., Jahanifar M., Shephard A., Dexl J., Wittenberg T., Kondo S., Lafarge MW., Koelzer VH., Liang J., Wang Y., Long X., Liu J., Razavi S., Khademi A., Yang S., Wang X., Erber R., Klang A., Lipnik K., Bolfa P., Dark MJ., Wasinger G., Veta M., Breininger K.:
  Mitosis domain generalization in histopathology images — The MIDOG challenge
  In: Medical Image Analysis 84 (2023), Article No.: 102699
  ISSN: 1361-8415
  DOI: 10.1016/j.media.2022.102699
  BibTeX: Download
• Fragoso-Garcia M., Wilm F., Bertram CA., Merz S., Schmidt A., Donovan T., Fuchs-Baumgartinger A., Bartel A., Marzahl C., Diehl L., Puget C., Maier A., Aubreville M., Breininger K., Klopfleisch R.:
  Automated diagnosis of 7 canine skin tumors using machine learning on H&E-stained whole slide images
  In: Veterinary Pathology (2023)
  ISSN: 0300-9858
  DOI: 10.1177/03009858231189205
  BibTeX: Download

Conference Contributions

• Qiu J., Wilm F., Öttl M., Schlereth M., Liu C., Heimann T., Aubreville M., Breininger K.:
  Adaptive Region Selection for Active Learning in Whole Slide Image Semantic Segmentation
  In: The 26th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI 2023) 2023
  DOI: 10.48550/arXiv.2307.07168
  BibTeX: Download
• Wilm F., Fragoso M., Marzahl C., Qiu J., Puget C., Diehl L., Bertram CA., Klopfleisch R., Maier A., Breininger K., Aubreville M.:
  Abstract: Pan-tumor CAnine CuTaneous Cancer Histology (CATCH) Dataset
  Bildverarbeitung für die Medizin Workshop, BVM 2023 (Braunschweig, July 2, 2023 - July 4, 2023)
  In: Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus Maier-Hein, Christoph Palm, Thomas Tolxdorff (ed.): Informatik aktuell 2023
  DOI: 10.1007/978-3-658-41657-7_45
  BibTeX: Download
• Aubreville M., Stathonikos N., Bertram CA., Klopfleisch R., ter Hoeve N., Ciompi F., Wilm F., Marzahl C., Donovan TA., Maier A., Veta M., Breininger K.:
  Abstract: the MIDOG Challenge 2021 Mitosis Domain Generalization in Histopathology Images
  Bildverarbeitung für die Medizin Workshop, BVM 2023 (Braunschweig, July 2, 2023 - July 4, 2023)
  In: Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus Maier-Hein, Christoph Palm, Thomas Tolxdorff (ed.): Informatik aktuell 2023
  DOI: 10.1007/978-3-658-41657-7_26
  BibTeX: Download
• Öttl M., Steenpaß J., Rübner M., Geppert CI., Qiu J., Wilm F., Hartmann A., Beckmann M., Fasching P., Maier A., Erber R., Breininger K.:
  Improved HER2 Tumor Segmentation with Subtype Balancing Using Deep Generative Networks
  20th IEEE International Symposium on Biomedical Imaging, ISBI 2023 (Cartagena, April 18, 2023 - April 21, 2023)
  In: Proceedings - International Symposium on Biomedical Imaging 2023
  DOI: 10.1109/ISBI53787.2023.10230503
  BibTeX: Download
• Wilm F., Fragoso M., Bertram CA., Stathonikos N., Ottl M., Qiu J., Klopfleisch R., Maier A., Aubreville M., Breininger K.:
  Mind the Gap: Scanner-Induced Domain Shifts Pose Challenges for Representation Learning in Histopathology
  20th IEEE International Symposium on Biomedical Imaging, ISBI 2023 (Cartagena, April 18, 2023 - April 21, 2023)
  In: Proceedings - International Symposium on Biomedical Imaging 2023
  DOI: 10.1109/ISBI53787.2023.10230458
  BibTeX: Download
• Wilm F., Fragoso M., Bertram CA., Stathonikos N., Öttl M., Qiu J., Klopfleisch R., Maier A., Breininger K., Aubreville M.:
  Multi-scanner Canine Cutaneous Squamous Cell Carcinoma Histopathology Dataset
  Bildverarbeitung für die Medizin Workshop, BVM 2023 (Braunschweig, July 2, 2023 - July 4, 2023)
  In: Thomas M. Deserno, Heinz Handels, Andreas Maier, Klaus Maier-Hein, Christoph Palm, Thomas Tolxdorff (ed.): Informatik aktuell 2023
  DOI: 10.1007/978-3-658-41657-7_46
  BibTeX: Download
• Ammeling J., Wilm F., Ganz J., Breininger K., Aubreville M.:
  Reference Algorithms for the Mitosis Domain Generalization (MIDOG) 2022 Challenge
  25th International Conference on Medical Image Computing and Computer-Assisted Intervention , MICCAI 2022 (Singapore, SGP, September 18, 2022 - September 22, 2022)
  In: Bin Sheng, Marc Aubreville (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2023
  DOI: 10.1007/978-3-031-33658-4_19
  BibTeX: Download

2022

Journal Articles

• Wilm F., Fragoso M., Marzahl C., Qiu J., Puget C., Diehl L., Bertram CA., Klopfleisch R., Maier A., Breininger K., Aubreville M.:
  Pan-tumor CAnine cuTaneous Cancer Histology (CATCH) dataset
  In: Scientific Data 9 (2022), Article No.: 588
  ISSN: 2052-4463
  DOI: 10.1038/s41597-022-01692-w
  BibTeX: Download
• Marzahl C., Hill J., Stayt J., Bienzle D., Welker L., Wilm F., Voigt J., Aubreville M., Maier A., Klopfleisch R., Breininger K., Bertram CA.:
  Inter-species cell detection - datasets on pulmonary hemosiderophages in equine, human and feline specimens
  In: Scientific Data 9 (2022)
  ISSN: 2052-4463
  DOI: 10.1038/s41597-022-01389-0
  BibTeX: Download
• Bertram CA., Aubreville M., Donovan TA., Bartel A., Wilm F., Marzahl C., Assenmacher CA., Becker K., Bennett M., Corner S., Cossic B., Denk D., Dettwiler M., Gonzalez BG., Gurtner C., Haverkamp AK., Heier A., Lehmbecker A., Merz S., Noland EL., Plog S., Schmidt A., Sebastian F., Sledge DG., Smedley RC., Tecilla M., Thaiwong T., Fuchs-Baumgartinger A., Meuten DJ., Breininger K., Kiupel M., Maier A., Klopfleisch R.:
  Computer-assisted mitotic count using a deep learning–based algorithm improves interobserver reproducibility and accuracy
  In: Veterinary Pathology 59 (2022), p. 211-226
  ISSN: 0300-9858
  DOI: 10.1177/03009858211067478
  BibTeX: Download
• Wilm F., Benz M., Bruns V., Baghdadlian S., Dexl J., Hartmann D., Kuritcyn P., Weidenfeller M., Wittenberg T., Merkel S., Hartmann A., Eckstein M., Geppert CI.:
  Fast whole-slide cartography in colon cancer histology using superpixels and CNN classification
  In: Journal of Medical Imaging 9 (2022)
  ISSN: 2329-4310
  DOI: 10.1117/1.JMI.9.2.027501
  BibTeX: Download
• Bertram CA., Aubreville M., Donovan TA., Bartel A., Wilm F., Marzahl C., Assenmacher CA., Becker K., Bennett M., Corner S., Cossic B., Denk D., Dettwiler M., Gonzalez BG., Gurtner C., Haverkamp AK., Heier A., Lehmbecker A., Merz S., Noland EL., Plog S., Schmidt A., Sebastian F., Sledge DG., Smedley RC., Tecilla M., Thaiwong T., Fuchs-Baumgartinger A., Meuten DJ., Breininger K., Kiupel M., Maier A., Klopfleisch R.:
  Computer Assistance: A New Gold Standard for the Mitotic Count?
  In: Journal of Comparative Pathology 191 (2022)
  ISSN: 0021-9975
  DOI: 10.1016/j.jcpa.2021.11.017
  BibTeX: Download

Conference Contributions

• Wilm F., Marzahl C., Breininger K., Aubreville M.:
  Domain Adversarial RetinaNet as a Reference Algorithm for the MItosis DOmain Generalization Challenge
  24th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2021 (Strasbourg, FRA, September 27, 2021 - October 1, 2021)
  In: Marc Aubreville, David Zimmerer, Mattias Heinrich (ed.): Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) 2022
  DOI: 10.1007/978-3-030-97281-3_1
  BibTeX: Download

2021

Conference Contributions

• Marzahl C., Wilm F., Dressler FF., Tharun L., Perner S., Bertram CA., Kröger C., Voigt J., Klopfleisch R., Maier A., Aubreville M., Breininger K.:
  Robust Quad-Tree based Registration on Whole Slide Images
  MICCAI Computational Pathlogy (COMPAY) Workshop
  BibTeX: Download
• Marzahl C., Bertram CA., Wilm F., Voigt J., Barton AK., Klopfleisch R., Breininger K., Maier A., Aubreville M.:
  Cell Detection for Asthma on Partially Annotated Whole Slide Images: Learning to be EXACT
  German Workshop on Medical Image Computing, 2021 (Regensburg, March 7, 2021 - March 9, 2021)
  In: Christoph Palm, Heinz Handels, Klaus Maier-Hein, Thomas M. Deserno, Andreas Maier, Thomas Tolxdorff (ed.): Informatik aktuell 2021
  DOI: 10.1007/978-3-658-33198-6_36
  BibTeX: Download
• Bertram CA., Donovan TA., Tecilla M., Bartenschlager F., Fragoso M., Wilm F., Marzahl C., Breininger K., Maier A., Klopfleisch R., Aubreville M.:
  Dataset on Bi- and Multi-nucleated Tumor Cells in Canine Cutaneous Mast Cell Tumors
  German Workshop on Medical Image Computing, 2021 (Regensburg, March 7, 2021 - March 9, 2021)
  In: Christoph Palm, Heinz Handels, Klaus Maier-Hein, Thomas M. Deserno, Andreas Maier, Thomas Tolxdorff (ed.): Informatik aktuell 2021
  DOI: 10.1007/978-3-658-33198-6_33
  BibTeX: Download
• Wilm F., Bertram CA., Marzahl C., Bartel A., Donovan TA., Assenmacher CA., Becker K., Bennett M., Corner S., Cossic B., Denk D., Dettwiler M., Gonzalez BG., Gurtner C., Heier A., Lehmbecker A., Merz S., Plog S., Schmidt A., Sebastian F., Smedley RC., Tecilla M., Thaiwong T., Breininger K., Kiupel M., Maier A., Klopfleisch R., Aubreville M.:
  Influence of Inter-Annotator Variability on Automatic Mitotic Figure Assessment
  German Workshop on Medical Image Computing, 2021 (Regensburg, March 7, 2021 - March 9, 2021)
  In: Christoph Palm, Heinz Handels, Klaus Maier-Hein, Thomas M. Deserno, Andreas Maier, Thomas Tolxdorff (ed.): Informatik aktuell 2021
  DOI: 10.1007/978-3-658-33198-6_56
  BibTeX: Download
• Theelke L., Wilm F., Marzahl C., Bertram CA., Klopfleisch R., Maier A., Aubreville M., Breininger K.:
  Iterative Cross-Scanner Registration for Whole Slide Images
  IEEE/CVF International Conference on Computer Vision (ICCVW)
  In: 2021 IEEE/CVF INTERNATIONAL CONFERENCE ON COMPUTER VISION WORKSHOPS (ICCVW 2021), LOS ALAMITOS: 2021
  DOI: 10.1109/ICCVW54120.2021.00071
  BibTeX: Download

2018

Conference Contributions

• Stefke A., Wilm F., Richer R., Gradl S., Eskofier B., Forster C., Namer B.:
  "MigraineMonitor" – Towards a System for the Prediction of Migraine Attacks using Electrostimulation
  52th Annual Conference of the German Society for Biomedical Engineering (VDE|DGBMT) (Aachen, September 26, 2018 - September 28, 2018)
  In: Current Directions in Biomedical Engineering 2018
  DOI: 10.1515/cdbme-2018-0151
  URL: https://www.mad.tf.fau.de/files/2018/09/2018-StefkeWilm-DGBMT-MigraineMonitor.pdf
  BibTeX: Download